Heterogeneous nanomechanical properties of type I collagen in longitudinal direction
نویسندگان
چکیده
منابع مشابه
Nanomechanical sequencing of collagen: tropocollagen features heterogeneous elastic properties at the nanoscale.
Collagen is the most important structural protein in biology and is responsible for the strength and integrity of tissues such as bone, teeth, cartilage and tendon. Here we report a systematic computational sequencing of the effect of amino acid motif variations on the mechanical properties of single tropocollagen molecules, with a particular focus on elastic deformation at varying applied stra...
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Collagen fibrils play an important role in the human body, providing tensile strength to connective tissues. These fibrils are characterized by a banding pattern with a D-period of 67 nm. The proposed origin of the D-period is the internal staggering of tropocollagen molecules within the fibril, leading to gap and overlap regions and a corresponding periodic density fluctuation. Using an atomic...
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A new mathematical model is presented to describe the elastic and viscoelastic properties of a single collagen fiber. The model is formulated by accounting for the mechanical contribution of the collagen fiber's main constituents: the microfibrils, the interfibrillar matrix and crosslinks. The collagen fiber is modeled as a linear elastic spring, which represents the mechanical contribution of ...
متن کاملNanomechanics of Type I Collagen.
Type I collagen is the predominant collagen in mature tendons and ligaments, where it gives them their load-bearing mechanical properties. Fibrils of type I collagen are formed by the packing of polypeptide triple helices. Higher-order structures like fibril bundles and fibers are assembled from fibrils in the presence of other collagenous molecules and noncollagenous molecules. Curiously, howe...
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Objective- To determine the effect of collagen type I on hydroxyproline content in Achilles tendon in dogs. Design- Experimental in vivo study. Animals- A total of 12 adult dogs. Procedure- Under general anesthesia and aseptic condition the dorsal surface of right Achilles tendon was exposed and after complete separation of connective tissue, it was splitted (striking 10 times) in full thic...
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ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2017
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-016-0870-6